2. Signaling Pathways
  3. Metabolic Enzyme/Protease
  4. Drug Metabolite

Drug Metabolite

Drug Metabolite

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Drug metabolite results when a drug is metabolized into a modified form which continues to produce effects. Drug metabolism redox reactions such as heteroatom dealkylations, hydroxylations, heteroatom oxygenations, reductions, and dehydrogenations can yield active metabolites, and in rare cases even conjugation reactions can yield an active metabolite.

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-116016R
    Etilevodopa (Standard)
    Chlorbenside (Standard) is the analytical standard of Chlorbenside. This product is intended for research and analytical applications. Chlorbenside is an organochlorine pesticide. Chlorbenside targets organism such as mites and ticks and possesses efficient ovicidal and larvicidal activities.
    Etilevodopa (Standard)
  • HY-W743390
    Propylene thiourea-d6
    4-Methylimidazolidine-2-thione-d6 (4-Methylimidazolidine-2-thione-d6) is deuterium labeled 4-Methylimidazolidine-2-thione. Propylene thiourea is one of the main degradation products of Propineb (HY-119630) in animals, plants and during processing.
    Propylene thiourea-d<sub>6</sub>
  • HY-119359
    5,6-Epoxy-13-cis retinoic acid
    5,6-Epoxy-13-cis retinoic acid (Isotretinoin EP impurity G) is a metabolite of 13-cis retinoic acid.
    5,6-Epoxy-13-cis retinoic acid
  • HY-143907S
    Atorvastatin EP impurity H-d5
    Atorvastatin EP impurity H-d5 is the deuterium labeled Atorvastatin EP impurity H.
    Atorvastatin EP impurity H-d<sub>5</sub>
  • HY-100642S1
    3-O-Methyltolcapone-d4
    3-O-Methyltolcapone-d4 (Ro 40-7591 d4) is a deuterium labeled 3-O-Methyltolcapone (HY-174062). 3-O-Methyltolcapone (Ro 40-7591) is a metabolite of Tolcapone (HY-17406). Tolcapone (Ro 40-7592) is a selective, potent and orally active COMT inhibitor with an IC50of 773 nM. Tolcapone can inhibits α-syn and Aβ42 oligomerization and fibrillogenesis. Tolcapone can cause oxidative stress and induce cancer cells apoptosis and ROS production. Tolcapone can be used for the researches of cancer and neurological disease, such as Parkinson disease and neuroblastoma.
    3-O-Methyltolcapone-d<sub>4</sub>
  • HY-147327
    N-Formylsarcolysine
    N-Formylsarcolysine has antitumor activity, and inhibits leukemia by increasing the Hb and erythrocyte levels and decreasing the number of leukocytes. N-Formylsarcolysine also involves in glioblastoma and other diseases research.
    N-Formylsarcolysine
  • HY-W011235R
    Norfluoxetine hydrochloride (Standard)
    Arecoline (hydrobromide) (Standard) is the analytical standard of Arecoline (hydrobromide). This product is intended for research and analytical applications. Arecoline hydrobromide, a naturally occurring psychoactive alkaloid, is a partial agonist of nicotinic and muscarinic acetylcholine receptor. Arecoline hydrobromide exhibits stimulation, alertness, anxiolysis and anti-parasitic effects. Arecoline hydrobromide also can induce oxidative stress.
    Norfluoxetine hydrochloride (Standard)
  • HY-180671
    Uric acid riboside
    Uric acid riboside is a minor metabolite of Uric acid (HY-B2130) in butterfly wings.
    Uric acid riboside
  • HY-W050000R
    OR-1855 (Standard)
    OR-1855 (Standard) is an analytical standard of OR-1855 (HY-W050000). This product is intended for research and analytical applications. OR-1855, an active metabolite of Levosimendan (HY-14286), has effect on myometrial contractility. OR-1855 exerts anti-inflammatory effects by inhibiting IL-1β-induced ROS formation and NAD(P)H oxidase-dependent superoxide radical generation in HUVECs. OR-1855 inhibits IL-1β-induced phosphorylation p38 MAPK, ERK1/2, c-Jun and JNK in HUVECs. OR-1855 can be used for the study of inflammation.
    OR-1855 (Standard)
  • HY-137773
    N-Methyl pemetrexed
    N-Methyl pemetrexed is an impurity of Pemetrexed. Pemetrexed is an antifolate cytotoxic agent that can be used for the research of cancer.
    N-Methyl pemetrexed
  • HY-118548
    Tetranor-PGAM
    Tetranor-PGAM is a tetranor-prostaglandin A metabolite. Tetranor-PGAM is a dehydration product of tetranor-PGEM (HY-114988). Tetranor-PGAM can be measured as a surrogate for tetranor-PGEM levels in urine.
    Tetranor-PGAM
  • HY-10002S2
    Calcitriol-d9
    Calcitriol-d9 (1,25-Dihydroxyvitamin D3-d9) is the deuterium labeled Calcitriol (HY-10002). Calcitriol is the most active metabolite of vitamin D and also a vitamin D receptor (VDR) agonist.
    Calcitriol-d<sub>9</sub>
  • HY-W002112S1
    (±)-Nornicotine-d7
    (±)-Nornicotine-d7 is the deuterium labeled (±)-Nornicotine (HY-W002112). (±)-Nornicotine is a major metabolite of Nicotine. (±)-Nornicotine is a partial nAChRs agonist, specifically activating receptor subtypes containing α7 and α6 subunits. (±)-Nornicotine disrupts β-catenin and ZO-1, and induces F-actin depolymerization. (±)-Nornicotine supports self-administration behavior. (±)-Nornicotine can be used in the research of atherosclerosis, Alzheimer's disease, and schizophrenia.
    (±)-Nornicotine-d<sub>7</sub>
  • HY-113478R
    3β-Ursodeoxycholic acid (Standard)
    3β-Ursodeoxycholic acid (Standard) is the analytical standard of 3β-Ursodeoxycholic acid. This product is intended for research and analytical applications. 3β-Ursodeoxycholic acid (Isoursodeoxycholic acid) is a bile acid. 3β-Ursodeoxycholic acid shows good tolerance and well intestinal absorption by oral adminstation. 3β-Ursodeoxycholic acid can be isomerized by intestinal and hepatic enzymes to yield UDCA.
    3β-Ursodeoxycholic acid (Standard)
  • HY-143982S
    Mianserin EP impurity E-d4 (hydrochloride)
    Mianserin EP impurity E-d4 (hydrochloride) is the deuterium labeled Mianserin EP impurity E hydrochloride.
    Mianserin EP impurity E-d<sub>4</sub> (hydrochloride)
  • HY-116687
    7-Aminoflunitrazepam
    7-Aminoflunitrazepam is the main urinary metabolite of Flunitrazepam.
    7-Aminoflunitrazepam
  • HY-157690A
    19(R),20(S)-EDP
    19(R),20(S)-EDP (compound 19(S),20(R)-2a) is an oxylipin and a metabolite of docosahexaenoic acid (HY-B2167).
    19(R),20(S)-EDP
  • HY-W741628
    7-Aminonimetazepam-d3
    7-Aminonimetazepam-d3 is the deuterium labeled 7-Aminonimetazepam (HY-W088846). 7-Aminonimetazepam is the metabolite of Nimetazepam, which is found in the urine.
    7-Aminonimetazepam-d<sub>3</sub>
  • HY-W223348
    Org-9768
    Org-9768 (Compound (2-methyl-2,3-dihydro-1H-inden-2-yl)methanamine) is a drug intermediate for synthesizing the mitochondrial permeability transition pore (mPTP) inhibitor. Org-9768 can be used for the researches of neurological and cardiovascular disease, such as Parkinson's disease.
    Org-9768
  • HY-161125
    (+)-JQ1-OH
    (+)-JQ1-OH is the major metabolite of (+)-JQ1(HY-13030). (+)-JQ-1 (JQ1) is a potent, specific, and reversible BET bromodomain inhibitor, with IC50s of 77 and 33 nM for the first and second bromodomain (BRD4(1/2)). (+)-JQ-1 also activates autophagy.
    (+)-JQ1-OH
Cat. No. Product Name / Synonyms Application Reactivity